The integration of bioclimatic architecture and neuroarchitecture in educational environments such as the University of Guayaquil seeks to mitigate stress and improve cognitive well-being, especially in students with psychosensory and autism spectrum disorders. The design of spaces that take advantage of natural light, active contact with green areas, and soft color palettes—such as white, blue, and green—has shown a 65% decrease in sensory disturbances and a 50% increase in academic concentration. Complementarily, tactical urbanism is proposed as a tool for sustainable and participatory planning in vulnerable sectors of Guayaquil, such as Mapasingue, to transform degraded spaces through low-cost interventions. Although there is a gap in the local empirical literature, the convergence of these approaches underscores that physical design, based on sensory evidence and citizen participation, is fundamental to promoting mental health, energy efficiency, and social cohesion in contemporary urban development.